IntelliProbe | Rapid Diagnostek, Inc.

General Description
This is a highly versatile platform. The system consists of a cell phone-sized instrument that uses disposable sensors. Sensors can be for a single analyte or can be made as a multiplexed array on a single sensor. All sensor formats will be compatible with the same instrument. The system is intended for use at the point of sample collection, regardless of environment. Skills sufficient to use a cell phone are far above what is required to operate the system. While the first product will be a hand held device, the technology can also be configured as a low volume bench-top or a high throughput laboratory instrument. Test samples can be any untreated biological fluid, environmental sample, or a prepared solution or suspension of a material to be tested.

Technical Description
A bulk acoustic shear-wave thin-film resonator coated with a capture ligand is operated at its fundamental resonance frequency as it is exposed to a test sample. As target analyte is captured the phase of the signal shifts. The rate of phase change is proportional to concentration of target analyte in the sample. A second identical resonator on the sensor is coated as a reference that is non-reactive with the target analyte but will undergo any non-specific changes that the capture ligand on the test resonator experiences (pH, temperature, viscosity, non-specific protein binding, etc.). The net difference between the test and reference phase shifts is due solely to target analyte binding.

Evaluation Criteria

THROUGHPUT: