iScan System | Illumina, Inc. | WMD Detector Selector

General Description
The iScan System is a cutting-edge, dedicated array scanner that supports rapid, sensitive, and accurate imaging of Illumina's array-based genetic analysis products. The system features a high signal-to-noise ratio, high sensitivity, an excellent limit of detection, and a broad dynamic range leading to exceptionally high data quality. The iScan System supports Infinium, GoldenGate, DASL, Gene Expression (Direct Hybridization), and Methylation assays along with different multi-sample BeadChip formats.

Technical Description
At the System's core is the iScan Reader, which incorporates high-performance lasers, optics, and detection systems. The iScan Reader offers sub-micron resolution and unmatched throughput rates. Even the highest density BeadChips can be scanned in just minutes, allowing processing of up to 96 multi-sample BeadChips per day. These imaging features are especially beneficial for high-density genotyping, CNV analysis, DNA methylation, and gene expression profiling.

Evaluation Criteria

THROUGHPUT:

Greater than 8 hours for detection
Multiple samples, multiple tests/sample per run
Less than 32 samples every 2 hours
The system or device is currently semi-automated
Device or system is intended for multiple detection assays
5 or more solutions, buffer, eluents, and/or reagents
5 or more components
Less than 5 minutes is required for set-up
Greater than 12 steps are required for detection

LOGISTICS:

A day of training and technical skills are required
Approximately the size of a home dishwasher
More than 50 kg
System or device has 110V electrical requirement

OPERATIONS:

Can be used from 25°C to 37°C
Components must be frozen (-20°C)
Performance is not influenced by relative humidity
Between 1 to 6 months shelf life
Greater than 10 years expected life
Results cannot be viewed in real-time
The system could be adapted to a fully autonomous system with some effort
The system software is closed and not available for modification
The system hardware is closed and not available for modification

DETECTION:

Possible the system could receive 510K clearance, no current efforts at this time
Possible the system could receive FDA approval, no current efforts at this time
This system does not test liquids
Excellent specificity. System has occasional false alarms under certain conditions (<2%)
Manual kit not integrated with the system handles spore lysis

Tier Selection