Agilent 6200 Series Time of Flight Mass Spectrometer | Agilent Technologies, Inc.

General Description
The 6200 series instruments are time of flight mass spectrometers designed to be coupled to liquid chromatography systems for sample separation and introduction. They are compatible with electrospray ionization (ESI), atmospheric pressure chemical ionization (APCI), and atmospheric pressure photoionization (APPI) for the introduction and ionization of liquid samples. Additionally, the 6200 series instruments can be combined with desorption electrospray ionization (DESI) and/or direct analysis in real time (DART) ionization sources for the introduction and ionization of solids. The information obtained from the 6200 series instruments can be used to identify and unknown compound and/or determine how much of a particular compound is present in a sample. The 6200 series achieve industry-leading TOF mass resolution and mass accuracy without sacrificing data acquisition speed, dynamic range, mass range, or sensitivity. They provide speed needed for ultra-high pressure LC (UHPLC) separations, plus performance needed for analysis of complex, real-world samples.

Data acquisition rates up to 20 spectra per second
Up to five orders in-spectrum dynamic range reveals trace-level targets in presence of vastly more abundant compounds.
Exceptional sensitivity finds and identifies compounds at extremely low concentrations.

Technical Description
The 6200 series is comprised of 2 different models of TOF mass spectrometer. They each feature 2-3 ppm mass accuracy and 20,000 FWHM resolution suitable all your accurate mass analytical challenges. Both 6200 series QTOF instruments incorporate the following technology:

Proprietary orthogonal spray ion source maximizes ion generation and reduces noise.
Proprietary INVAR flight tube sealed in vacuum-insulated shell eliminates thermal mass drift due to temperature changes, maintaining excellent mass accuracy, 24/7.
Analog-to-digital (ADC) detection records multiple ion events, allowing very accurate mass assignments over a wide mass range and dynamic range of concentrations.
4GHz ADC electronics enable high sampling rate (32 Gbit/s), improving resolution, mass accuracy, and sensitivity for low-abundance samples.

Evaluation Criteria

THROUGHPUT:

Between 15 and 30 minutes for detection
Multiple samples, multiple tests/sample per run
The system or device is currently fully automated
Device or system is intended for multiple detection assays
0-1 solutions, buffer, eluents, and/or reagents
Greater than 20 minutes is required is required for setup
Almost instantaneous detection

LOGISTICS:

More than a day of training and significant technical skills are required
Approximately the size of a home dishwasher
More than 50 kg
Wired connections are available
System or device has 220V electrical requirement

OPERATIONS:

Can be used from 4°C to 37°C
Components must be stored at room temperature (27°C)
Device or system has peak performance at normal relative humidity conditions
5-10 years expected life
Results can be viewed in real-time
The system is not capable of autonomy
The system software is closed and not available for modification
The system hardware is closed and not available for modification

DETECTION:

Possible the system could receive 510K clearance, no current efforts at this time
Possible the system could receive FDA approval, no current efforts at this time
Excellent specificity. System has occasional false alarms under certain conditions (<2%)
System currently can identify aerosolized chemical agent
System currently can identify liquid chemical agent

Tier Selection