Agilent 6400 Series Triple Quadrupole Mass Spectrometer | Agilent Technologies, Inc.

General Description
The 6400 series instruments are triple quadrupole mass spectrometers designed to be coupled to a liquid chromatography system for sample separation and introduction. The information obtained from the 6400 series instruments can be used to confirm the identity of a compound or determine how much of a particular compound is present. Agilent 6400 Series Triple Quadrupoles are designed and constructed using the latest electronics and hardware manufacturing techniques. The Hyperbolic quadrupole provides unrivaled ion transmission and spectral resolution. The high-pressure hexapole collision cell with linear acceleration yields optimized MS/MS fragmentation without cross-talk effects. The off-axis, high-energy dynode detector enables rapid polarity switching, with low noise, and delivers the widest dynamic range available. The 6400 Series Triple Quadrupole instruments are integrated with MassHunter software, which contains the Autotune algorithm and numerous other data acquisition and processing tools, to deliver the highest quantitative performance available.

Technical Description
The 6400 series Triple Quadrupole LC/MS system is a family of instruments comprised of 4 different models of triple quadrupole mass spectrometer. These instruments have a variety of performance characteristics. The 6420 is economical and easy to use, a perfect workhorse instrument. The 6430 offers improved sensitivity to yield more precise quantitation for most assays. The 6460 adds Agilent Jet Stream Technology to dramatically increase sensitivity. The 6490 Includes novel iFunnel technology for ultra trace quantitation to address your most demanding quantitative applications. Triggered MRM (tMRM) acquisition is available on all Agilent 6400 Series Triple Quadrupole LC/MS Systems, enabling quantitative and qualitative analysis in a single run. Triggered MRM acquisition effectively combines MRM quantitative analysis with data dependent acquisition of a product ion spectrum for use in library search, identification, and confirmation. tMRM product ion spectra can be searched against application-specific libraries, such as the Agilent Personal Compound Database and Library (PCDL), or large public spectral libraries.

Evaluation Criteria

THROUGHPUT:

Between 15 and 30 minutes for detection
Multiple samples, multiple tests/sample per run
95-32 samples every 2 hours
The system or device is currently fully automated
0-1 solutions, buffer, eluents, and/or reagents
10-20 minutes is required for setup

LOGISTICS:

More than a day of training and significant technical skills are required
Approximately the size of a home dishwasher
More than 50 kg
Wireless and wired connections are available
System or device has 220V electrical requirement

OPERATIONS:

Can be used from 4°C to 37°C
This system does not require consumable components
Device or system has peak performance at normal relative humidity conditions
5-10 years expected life
Results cannot be viewed in real-time
The system is not capable of autonomy
The system software is closed and not available for modification
The system hardware is closed and not available for modification

DETECTION:

Possible the system could receive 510K clearance, no current efforts at this time
Possible the system could receive FDA approval, no current efforts at this time
Excellent specificity. System has occasional false alarms under certain conditions (<2%)
System currently can identify aerosolized chemical agent
System currently can identify liquid chemical agent

Tier Selection