Agilent 6500 Series Quadrupole Time of Flight Mass Spectrometer | Agilent Technologies, Inc.

General Description
The 6500 series instruments are quadrupole time of flight mass spectrometers (QTOF) designed to be coupled to liquid chromatography systems for sample separation and introduction. They provide accurate mass (<1 ppm mass error) and high resolution (>42,000 FWHM) required for compound identification. They are compatible with a wide-range of ionization techniques, please contact POC for more information. The 6500 series instruments can be used to identify unknown compounds, confirm identity of compounds or determine how much of a compound is present in samples.

Technical Description
The 6500 series is comprised of 3 different models of QTOF mass spectrometer with a variety of performance characteristics to meet any budgetary and/or application need. The 6520 is the workhorse QTOF instrument, providing 2 ppm mass accuracy and 20,000 FWHM resolution suitable for most routine analyses. The 6540 instrument provides 1 ppm mass accuracy and 40,000 resolution for those more demanding applications. Designed for the most challenging assays, the 6550 QTOF with Ion Funnel Technology provides <1 ppm mass accuracy and >40,000 FWHM resolution and is the most sensitive accurate mass instrument available. All 6500 series QTOF instruments incorporate the following technology:

Proprietary orthogonal spray ion source maximizes ion generation and reduces noise, while maintaining excellent accurate mass with automated introduction of an internal reference mass.
Pioneering design of the collision cell and ion optics allows same reference mass calibration to be used for both MS and MS/MS. Resulting MS mass accuracy and precise isotopic ratios greatly improve confidence in molecular formula generation.
Proprietary INVAR flight tube sealed in vacuum-insulated shell eliminates thermal mass drift due to temperature changes, maintaining excellent mass accuracy, 24/7.
Analog-to-digital (ADC) detection records multiple ion events, allowing very accurate mass assignments over a wide mass range and dynamic range of concentrations.
4GHz ADC electronics enable high sampling rate (32 Gbit/s), improving resolution, mass accuracy, and sensitivity for low-abundance samples.
Dual gain amplifiers simultaneously process detector signals through both low-gain and high gain channels, extending dynamic range to 10x5.

Evaluation Criteria

THROUGHPUT:

Between 15 and 30 minutes for detection
Multiple samples, multiple tests/sample per run
95-32 samples every 2 hours
The system or device is currently fully automated
Device or system is intended for multiple detection assays
0-1 solutions, buffer, eluents, and/or reagents
Greater than 20 minutes is required for setup
Almost instantaneous detection

LOGISTICS:

More than a day of training and significant technical skills are required
Approximately the size of a home dishwasher
More than 50 kg
Wireless and wired connections are available
System or device has 220V electrical requirement

OPERATIONS:

Can be used from 4°C to 37°C
Components must be stored at room temperature (27°C)
Device or system has peak performance at normal relative humidity conditions
5-10 years expected life
Results can be viewed in real-time
The system is not capable of autonomy
The system software is closed and not available for modification
The system hardware is closed and not available for modification

DETECTION:

Possible the system could receive 510K clearance, no current efforts at this time
Possible the system could receive FDA approval, no current efforts at this time
Superior specificity. System has a false alarm rate approaching zero (~0%)
< 1 ppb
System currently can identify aerosolized chemical agent
System currently can identify liquid chemical agent

Tier Selection