General Description
The NQAD is a Universal HPLC detector that can be used in-line with other detectors or as the detector of choice for various HPLC analyses including UHPLC, HPLC, GPC, and SFC. The NQAD line of detectors utilizes water condensation nucleation technology which does not rely on a specific characteristic of the compound to be detected. The detector first nebulizes the HPLC stream then, second, evaporates the mobile phase leaving a dried aerosol particle. Third, water is condensed on the particle to increase its size. Only then is each particle individually counted. At a basic level, the NQAD is a particle counter that works well as a mass counter as well. With a strong separation method, the NQADs high sensitivity, linearity, wide dynamic range and high reproducibility lead to nanogram on column sensitivity. Detection does not rely on a specific characteristic of the compound; therefore, no derivatization is needed. The detector works well with gradient methods, mobile phases of any pH, is linear over 3-4 orders of magnitude and displays a peak reading in real time.
Technical Description
The Quant line of NQAD detectors utilizes “Water Condensation Nucleation” technology. This technology has been used in air particle analyzers, which are generally used for clean room analysis and environmental monitoring. In addition, it has been used as a nonvolatile residue monitor that tests the amount of nonvolatile residue in ultrapure water system (crucial in the semiconductor industry). The NQAD line of detectors was created by taking this robust technology and applying it to chromatography.
Evaluation Criteria
THROUGHPUT:
- 2 minutes or less for detection
- Multiple samples, multiple tests/sample per run
- The system or device is currently fully automated
- Device or system is intended for multiple detection assays
- 2 solutions, buffer, eluents, and/or reagents
- 1 component
- 10-20 minutes is required for set-up
- 1-2 steps are required for detection
LOGISTICS:
- Very brief (minutes-hours) training and minimal technical skills
- Approximately the size of a toaster
- Between 5 and 25 kg
- Wired connections are available
- System or device has 110V electrical requirement
OPERATIONS:
- Can be used from 25°C to 37°C
- Components must be stored at room temperature (27°C)
- Performance is not influenced by relative humidity
- Between 1 to 6 months shelf life
- Greater than 10 years expected life
- Results can be viewed in real-time
- The system could easily be adapted into a fully autonomous system
- The system hardware is open but modification requires licensing
DETECTION:
- Less than 10 µL
- Superior specificity. System has a false alarm rate approaching zero (~0%)
- 1 ppb-1 ppm
- Possible system could identify liquid chemical agent
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