Chemical-Biological Detection System (CBDS) | Science & Engineering Services, Inc.

General Description
The Chemical-Biological Detection System (CBDS) is sized and designed to deliver next generation capabilities beyond the current CBMS Block II. CBDS utilizes an integrated mass analyzer for analysis and identification of CWA, TIC and BWA materials; with collection of CWA, TIC and BWA hazards accomplished via air-stack as well as collection of CWA and TIC hazards via ground probe and/or direct injection. A key attribute of CBDS is the ability to create and transfer library updates of new hazards and/or unknowns within a few hours. In terms of logistics, the consumables cost per sample is less than one dollar and train-up for non-technical users is one day.

Technical Description
The Chemical-Biological Detection System (CBDS) uses a hexapole ion-trap mass spectrometer in which MS/MS is conducted either via AP-MALDI of biological samples or via chemical ionization of chemical samples. Biological materials undergo automated single-spot proteomic processing and MS/MS targeted bio-marker analysis to sift rapidly thru clutter against specialized-onboard and/or commercial internet-accessible databases. Chemical materials undergo similar steps, less single-spot proteomics processing.

Evaluation Criteria

THROUGHPUT:

Between 2 and 15 minutes for detection
Multiple samples, multiple tests/sample per run
95-32 samples every 2 hours
The system or device is currently fully automated
Device or system is intended for multiple detection assays
3 solutions, buffer, eluents, and/or reagents
1 component
10-20 minutes is required for set-up
1-2 steps are required for detection

LOGISTICS:

An afternoon of training and some technical skills required
Approximately the size of a home dishwasher
More than 50 kg
Satellite and wired connections are available
System or device has 110V electrical requirement

OPERATIONS:

Can be used from 4°C to 41°C
Components must be stored at 4°C
Performance is not influenced by relative humidity
Between 1 to 3 years shelf life
Greater than 10 years expected life
Results can be viewed in real-time
The system or device is currently fully autonomous
The system software is open and available for modification
The system hardware is open and available for modification

DETECTION:

Not possible for the system to achieve 510K clearance
Possible the system could receive FDA approval, no current efforts at this time
Less than 10 µL
Excellent specificity. System has occasional false alarms under certain conditions (<2%)
1,000-10,000 CFU per mL
1,000-10,000 PFU per mL
10-100 ng per mL
Fully automated spore lysis
1x10-4–1x10-3 mg/m3
1 ppb–1 ppm
System can currently identify aerosolized chemical agent
System can currently identify liquid chemical agent